This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in


Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Pepsin is a gastric enzyme released on cleavage of pepsinogens. Pepsinogens are precursor proteins produced by the gastric glands. Secretion in an inactive form limits self-digestion.

Cleavage is triggered by:

  • gastric acidity
  • the auto-catalytic activity of pepsin on pepsinogen

Pepsin acts to break bonds within polypeptide chains, particularly those near phenylalanine, tyrosine or leucine residues, to yield smaller peptides. It is an endopeptidase.

Pepsin is optimally active at gastric acidity; within the duodenum, the increase in pH reduces proteolytic activity.

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.


Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.