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Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Secretin is a gastrointestinal hormone that originating from S cells in the duodenum and upper jejunal mucosa in response to intraluminal acid.

It is a polypeptide of 27 amino acids.

Functions include:

  • stimulation of pancreatic bicarbonate secretion
  • enhanced secretion of pancreatic enzymes in response to cholecystokinin
  • inhibition of acid secretion; stimulation of pepsin secretion
  • causes a rapid rise in gastrin levels in a patient with a gastrinoma
  • increased flow of hepatic bile
  • increased glucose-induced insulin secretion

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