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Pathogenic determinants

Authoring team

Bacillus anthracis has a number of pathogenic determinants:

  • toxins: it produces an extracellular toxin which is lethal to experimental animals. It consists of three components:
    • oedema factor; has adenylate cyclase activity
    • protective antigen; antibody raised to this responsible for acquired immunity
    • lethal factor
  • exoenzymes
  • colonization factors
  • structural adaptations e.g. antiphagocytic capsule composed of poly-D-glutamate

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