This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Immunology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Protective immunity in leprosy is associated with T-cell mediated immunity. A patient with tuberculoid leprosy shows a strong lymphoproliferative response to mitogens and to M. leprae antigens and would have a preponderance of infiltrating CD4 helper/inducer T cells in granulomas, with a few CD8 cells and only an occasional acid-fast bacillus. In lepromatous leprosy the opposite would occur with numerous acid-fast bacilli and negligible T cells in granulomas.

Only a minority of individuals exposed to M. leprae infection develop leprosy because they are able to resist disease by establishing protective immunity. HLA studies have revealed that HLA-DR2 has an association with the development of tuberculoid leprosy. Various other HLA associations are being investigated.

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.