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Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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This is a copper containing protein which normally binds 90% of the copper present in plasma. It is not a copper transport protein but mirrors changes in serum levels.

The normal plasma level is 1-2.7 micromoles per litre.

Serum ceruloplasmin is reduced in:

  • Wilson's disease
  • malnutrition
  • nephrotic syndrome

It is increased in:

  • pregnancy
  • oestrogen containing contraceptives
  • acute infection
  • some types of chronic liver disease
  • malignancy

Note that reference ranges may vary with different laboratories.

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