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Sedating tricyclic antidepressants

Authoring team

Anxious and agitated patients tend to respond best to sedating drugs.

Sedating drugs may be divided into those with more or less marked anti-muscarinic effects:

  • relatively strong anti-muscarinic effects:
    • amitriptyline
    • clomipramine

  • relatively weak anti-muscarinic effects:
    • doxepin
    • mianserin
    • trazodone

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