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Sedating tricyclic antidepressants

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Anxious and agitated patients tend to respond best to sedating drugs.

Sedating drugs may be divided into those with more or less marked anti-muscarinic effects:

  • relatively strong anti-muscarinic effects:
    • amitriptyline
    • clomipramine

  • relatively weak anti-muscarinic effects:
    • doxepin
    • mianserin
    • trazodone

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