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Pathophysiology

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Essentially, chronic inflammation is caused by one of two means:

  • a persistent inflammatory stimulus:
    • intracellular organisms e.g. tuberculosis
    • immune reactions against host tissue which is treated as being foreign e.g. rheumatoid arthritis
    • foreign substances which cannot be degraded e.g. asbestos
  • ineffective inflammatory mechanisms:
    • absent or disordered inflammatory cells e.g. Chediak-Higashi syndrome
    • absent or disordered inflammatory mediators e.g. hypogammaglobulinaemia
    • global deficits e.g.:
      • poor nutrition
      • old age
      • immunocompromise e.g. AIDS

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