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Long term

Authoring team

Long term drug side effects include:

  • adaptive changes: - beta-blockers and upregulation of beta adrenoceptors during therapy - tardive dyskinesia and dopamine antagonists
  • rebound phenomena: - sudden withdrawal - again, seen with beta blockers and corticosteroids - need to withdraw drug very slowly - 1mg at a time, once a month
  • other: - chloroquine in the retina, amiodarone and deposition of phospholipids in tissues

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