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Immune phase

Authoring team

During the immune phase of leptospirosis about 50% of patients develop meningism, of whom about 33% have CSF lymphocytosis and raised protein in the CSF.

Generally the patients then make an uneventful recovery.

A minority of patients go on to develop:

  • tender hepatomegaly
  • jaundice
  • haemolytic anaemia
  • oliguric renal failure with microscopic haematuria
  • sometimes cardiac involvement with atrial and ventricular dysrhythmias and congestive heart failure

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