This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Calculation

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Creatinine clearance = (UV / P) ml per minute, where:

  • concentration of creatinine in urine = U
  • concentration of creatinine in plasma = P
  • volume of urine collected in T minutes = V

This formula shows SI units.

  • UV Amount of creatinine in 24h of urine is reported by the lab in mmol/24h; multiply by 1000 to convert to micromols
  • P Serum creatinine is reported in micromols/l; multiply by 1000 to do calculation for mls
  • 1440 Number of minutes in 24h CrCl(mls per min) = UVx1000x1000/(Px1440)

Alternatively, if urinary collection is difficult, the Cockcroft-Gault equation aims to predict creatinine clearance from knowledge of serum creatinine, age and weight:

  • creatinine clearance = (((140 - age in years) x (wt in kg)) x 1.23) / (serum creatinine in micromol/l)

For women multiply the result of calculation by 0.85.

The second calculation is unreliable if the patient has unstable renal function, is very obese, or is oedematous.

Reference:

  1. Cockcroft D (1976). Nephron, 16, 31.

Create an account to add page annotations

Create a free account

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.