Tissue injury or necrosis

• acute myocardial infarction - the rise in CRP appears within 24-48 hrs. The level begins to fall by the third day and becomes negative after 1-2 weeks. The rise of CRP correlates with peak CK-MB levels but CRP occurs 1-3 days later. If the CRP remains high then this indicates tissue damage in the heart or elsewhere. CRP is not raised in angina, if there is no tissue damage
• infarction of other tissues
• rejection of kidney or marrow transplant
• malignancy, especially lung, colon, breast
• following surgery - usually begins to rise within 4-6 hrs to peak at 48-72 hrs. The failure to fall indicates possible infection
• burns

Reference

1. Vanderschueren S et al. Extremely elevated C-reactive protein. Eur J Intern Med. 2006 Oct;17(6):430-3