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Pharmacodynamic variation

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Pharmacodynamic variation of drug activity instigating side effects may be seen in the following situations:

  • hepatic disease - able to enhance effects of drugs on CNS - e.g. opiates in cirrhotics can cause encephalopathy
  • altered fluid and electrolyte balance - e.g. digoxin and potassium

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