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Clinical features

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

This condition presents with sudden onset of illness in children under a year old, with features as follows:

  • prodome with listlessnes, diarrhoea, vomiting, pyrexia
  • circulatory collapse and shock, which is resistant to normal resuscitation measures
  • encephalopathy - coma, hypotonia, fits
  • acidosis
  • impaired renal and hepatic function

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