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Causes of thyrotoxicosis with low radioiodine uptake

Authoring team

Most patients with thyrotoxicosis have an increased uptake of radioiodine.

The causes of reduce uptake of radioiodine when scanning the thyroid of a thyrotoxic patient include:

  • thyroxine abuse or overdose
  • ectopic thyroid tissue:
    • struma ovarii
  • amiodarone
  • iodine ingestion and the Jod-Basedow effect

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