mefloquine half-life is approximately 21 days - therefore elimination from the body is extremely slow
mefloquine has no specific antidote
mefloquine is non-dialysable
there is a suggestion that oral activated charcoal may enhance elimination of mefloquine - this however has been incompletely studied
often milder symptoms resolve spontaneously - therefore they require neither specific therapy or change of prophylactic drug
if stopping mefloquine is indicated then mefloquine should be replaced with an alternative malaria chemoprophylaxis if the patient remains at risk of malaria transmission
clinicians should seek expert advice if in doubt regarding management
seizures secondary to mefloquine treatment should be treated with standard anti-convulsant therapy
psychosis secondary to mefloquine often requires supervision by a psychiatrist
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