This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Metabolism

Authoring team

Metabolism difference of drugs in children include:

  • deficient - hepatic oxidative metabolism - glucoronidase
  • diazepam - deficient hydroxylation in newborn
  • phenytoin hydroxylation - half life is 30 to 60 hours in neonate, 2 to 7 hours at one month, 20 to 30 hours as an adult
  • theophylline half life is 14 to 58 hours in premature neonate, 3.5 to 8 hours in adult
  • chloramphenicol - drug accumulates - vomiting, failure to suck, poor respiration, cyanosis, loose green stools, hypothermia, flaccidity, ashen-grey, aplastic anaemia

Create an account to add page annotations

Create a free account

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2025 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.