Depolarising muscle relaxants
The depolarising muscular relaxants act by mimicking acetylcholine. They bind to the postsynaptic receptor at the neuromuscular junction and cause a prolonged opening of ion channels due to a slow rate of dissociation. The postsynaptic membrane is thus briefly depolarised before becoming refractory to further stimulation.
The only drug of clinical value in this group is suxamethonium.
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