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Various drugs affect the half-life of theophylline:

  • increased half-life is seen in heart failure, cirrhosis, viral infections, and drugs e.g. erythromycin, ciprofloxacin, cimetidine
  • decreased half-life is seen in heavy drinkers, smokers, and by drugs e.g. barbiturates, phenytoin, carbamazepine, rifampicin

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