Method of action

• selectively block the action of leukotrienes on the respiratory tract. Leukotriene antagonists result in a reduction in mucus secretion, vascular permeability, and bronchoconstriction. There is also a reduction in eosinophil recruitment. Leukotriene antagonists result in an inhibition in early and late stage bronchoconstriction - indicating both a bronchodilatory and anti-inflammatory role
  
  
• there is no evidence to suggest that leukotriene antagonists provide protection against aspirin- or NSAID - induced anaphylaxis. Neither is there evidence that leukotriene antagonists benefit aspirin-sensitive asthmatics more than those without aspirin sensitivity.

Reference:

• MeReC Bulletin (1999), 1, 1-4.