Cellular actions
Serotonin is believed to act on at least three receptors:
- 5HT1:
- cause pre-synaptic inhibition of transmitter release
- inhibition of noradrenaline release peripherally
- inhibition of serotonin release centrally, negative feedback
- 5HT2:
- post-synaptic effects
- platelet aggregation e.g. during inflammation
- excitation and inhibition in CNS
- peripheral smooth muscle contraction
- 5HT3:
- central neurons targeted by ondansetron
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