CSM recommendations
Prolonged use of cyproterone may produce dose-related hepatotoxicity. Effects include:
- hepatitis
- cholestatic jaundice
- hepatic failure
- death
The Committee on the Safety of Medicine recommend that:
- long-term daily doses of 300 mg be restricted to:
- short courses to cover the effects of LHRH agonists or following orchidectomy
- patients who fail to respond to, or cannot tolerate, alternative treatments
- liver function tests are conducted before treatment and whenever hepatic impairment is suspected
- cyproterone is withheld once evidence of hepatotoxicity develops
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