HRT - equivalence options for different doses of transdermal oestradiol for women taking transdermal oestradiol only HRT with a separate progestogen or who do not require progestogen (women who have had a hysterectomy)

Equivalence options for different doses of transdermal oestradiol

• Evorel (25/50/75/100)
• Estradot patches (25/50/75/100)
• Estraderm patches (25/50/75/100)
• Femseven mono (50/75/100)
• Progynova TS (50/100)
• For a dose of 25 can use half a patch of 50.
• For a dose of 75 can use 3/4 of a patch of 100
  
  
• Alternatively, could switch to a gel preparation as Oestrogel or Sandrena or Lenzetto spray to take with current progestogen intake as above:
  • If taking Evorel 25: Oestrogel one measure a day would give an equivalent.
  • If taking Evorel 50: Oestrogel one measure twice a day would give an equivalent.
  • If taking Evorel 75: Oestrogel three measures a day (2am and 1pm or vice versa) would give an equivalent.
  • If taking Evorel 100: Oestrogel 4 measures a day (2am and 2pm) would give an equivalent.
  • Or Sandrena gel:
    • If taking Evorel 25: 0.5mg Sandrena sachet a day would give an equivalent.
    • If taking Evorel 50: 1mg Sandrena sachet a day would give an equivalent.
    • Or Lenzetto three sprays (40mcgm) equivalent to two measures of Oestrogel or 50 microgram patch

The respective Summary of Product Characteristics (SPCs) must be consulted before prescribing any drug mentioned.

Reference:

1. British Menopause Society. HRT preparations and equivalent alternatives Information for GPs and other health professionals