This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in


Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Oestrogens are renowned as female sex hormones, but they are also produced in small quantities in the male. They are C18 steroids derived from cholesterol via androgen intermediates.

They are synthesised in the:

  • ovaries within the:
    • theca interna
    • granulosa cells
    • corpus luteum
  • placenta during pregnancy
  • adrenal cortex
  • Leydig interstitial cells of the testis

The functions of oestrogens are varied; they are commonly associated with feminization and fertility.

The oestrogens produced naturally are 17beta-oestradiol, oestrone and oestriol.

  • oestrone (estrone E1)
    • formed from oestradiol in a reversible reaction
    • predominant form of circulating estrogen after menopause
    • oestrone is also a product of the peripheral conversion of androstenedione secreted by the adrenal cortex

  • oestradiol-17beta (estradiol E2)
    • primarily produced by theca and granulosa cells of the ovary
    • predominant form of oestrogen found in premenopausal women

  • oestriol (estriol E3)
    • oestrogen the placenta secretes during pregnancy
    • also is the peripheral metabolite of oestradiol and oestrone
    • is not secreted by the ovary

Oestrogen is involved in both female and male reproduction, as well as numerous other biological systems including the neuroendocrine, vascular, skeletal, and immune systems

  • also implicated in many different diseases and conditions such as infertility, obesity, osteoporosis, endometriosis, and a variety of cancers
  • works through its two distinct nuclear receptors, Estrogen Receptor (ER) alpha and ER beta
    • expression profiles of ER alpha and ER beta are unique
      • primary sites of ER alpha expression being the uterus and pituitary gland
      • main site of ER beta expression being the granulosa cells of the ovary

Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.


Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.