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Oral contraceptive pill and fibroids

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

  • evidence from Chiaffarino et al suggests at least a lack of association between the combined oral contraceptive and the risk of developing fibroids and a possible protective effect with long-term use

  • Chiaffarino undertook a case-control study in Milan - cases were collected from referrals for surgery because of menorrhagia or echographic signs of large myomas; controls came from a similar catchment area admitted for acute non-gynaecological, hormonal or neoplastic reasons (controls with a confirmed or suspected history of uterine fibroids were excluded)

  • the study revealed that women taking the pill had a significantly lower risk of fibroids which decreased with duration of use; women who had previously or never taken the pill had similar rates of development of fibroids; however pill use for less than a year showed an increased chance of fibroids; there was no association between risk of fibroids and time since stopping oral contraceptive use

A more recent study suggests that fibroids study should not be considered a contra-indication for OCs use.


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