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Thyroid dysfunction, congenital adrenal hyperplasia, hyperprolactinaemia, androgen-secreting tumours and Cushing’s syndrome must to be excluded before making a diagnosis of PCOS (1).
NICHD (1990) Diagnostic Criteria for PCOS is: |
Clinical Hyperandrogenism (Ferriman-Gallwey Score >8) or Biochemical Hyperandrogenism (Elevated Total/Free Testosterone) AND |
Oligomenorrhea (Less Than 6-9 Menses per Year) or Oligo-Ovulation AND |
Polycystic Ovaries on Ultrasound (>= 12 Antral Follicles in One Ovary or Ovarian Volume >= 10 cm3) |
Rotterdam (2003) Diagnostic criteria for PCOS - two out of three of: |
Clinical Hyperandrogenism (Ferriman-Gallwey Score >8) or Biochemical Hyperandrogenism (Elevated Total/Free Testosterone) OR |
Oligomenorrhea (Less Than 6-9 Menses per Year) or Oligo-Ovulation OR |
Polycystic Ovaries on Ultrasound (>= 12 Antral Follicles in One Ovary or Ovarian Volume >= 10 cm3) |
AE-PCOS Society (2009) Diagnostic Criteria for PCOS is: |
Clinical Hyperandrogenism (Ferriman-Gallwey Score >8) or Biochemical Hyperandrogenism (Elevated Total/Free Testosterone) PLUS Either of: |
Oligomenorrhea (Less Than 6-9 Menses per Year) or Oligo-Ovulation OR |
Polycystic Ovaries on Ultrasound (>= 12 Antral Follicles in One Ovary or Ovarian Volume >= 10 cm3) |
Suggested differential diagnoses and screening tests (6)
Reference:
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