Pyridoxine in PMS

• a meta-analysis has concluded that low doses of vitamin B6 (pyridoxine) are likely to improve the symptoms of premenstrual syndrome (1)
• there is no rationale for giving daily doses in excess of vitamin B6 in excess of 100mg.
• the authors of the meta-analysis conclude that vitamin B6 is probably effective in relieving overall premenstrual syndrome and in relieving PMS depression (1)
• pyridoxine can be suggested as a treatment for PMS, at least for the psychiatric symptoms (2)

Reference:

• BMJ 1999; 318:1375-81.
• Kashanian M1 et al. Pyridoxine (vitamin B6) therapy for premenstrual syndrome. Int J Gynaecol Obstet. 2007 Jan;96(1):43-4.