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Resistant ovary syndrome

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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"Resistant ovaries" result from a functional disturbance of the gonadotrophin receptors in the ovarian follicles. It may be a cause of primary or secondary amenorrhoea and is resistant to exogenous gonadotrophin stimulation.

Diagnosis of this condition requires that the patient has a normal 46,XX karyotype, normal secondary sexual characteristics, elevated plasma FSH and LH - in the menopausal range - and that normal, multiple follicles are seen on ovarian biopsy.

Spontaneous reversal of the receptor blockade may occur.

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