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Yolk sac tumour

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Less common germ cell ovarian tumours include:

  • endodermal sinus tumour or yolk sac tumour - accounts for 20% of malignant germ cell tumours; produces alpha-FP
  • embryonal carcinoma - rare; produces hCG and alpha-FP
  • non-gestational choriocarcinoma - rare; produces hCG

All occur in children and young women and grow rapidly. Most are unilateral.

Treatment consists of oophorectomy followed by combination chemotherapy, usually vinblastine, bleomycin and cis-platinum (VBP) or bleomycin, etoposide and cis-platinum (BEP).

The overall 5 year survival rate is about 60%.

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