This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Acute myeloid leukemia

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder characterised by the arrest of differentiation of the progenitor cells (“blasts”) coupled with an accumulation of immature progenitors in the bone marrow, resulting in hematopoietic failure (1).

  • AML is generally a disease of older adults - median age at diagnosis between 65 and 70 year of age
  • after age 5-10, every year of age worsens the prognosis for patients with AML
  • AML in older individuals is a more recalcitrant disease
    • the disease tends to be less proliferative with average bone marrow blast counts of 20% in those older than 60 and 40% in those younger than 60. When compared with those younger than 56, those older than 56 are less likely to have favorable cytogenetics (16% vs. 5%) and more likely to have unfavorable cytogenetics (33% vs. 50%)


Related pages

Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page