Diagnosis

The clinical features of aplastic anaemia are non-specific. Diagnosis is based upon:

• peripheral blood:
  • neutrophils less than 0.5 x 10^9 per litre
  • platelets less than 20 x 10^9 per litre
  • reticulocyte count corrected for haematocrit less than 1%
• marrow:
  • severe hypocellularity
  • moderate hypocellularity with < 30% of residual cells being haematopoietic

At least two peripheral plus one marrow criteria must be satisfied.

Reference

1. Kulasekararaj A, Cavenagh J, Dokal I, et al. Guidelines for the diagnosis and management of adult aplastic anaemia: a British Society for Haematology Guideline. Br J Haematol. 2024 Mar;204(3):784-804.