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Aprotinin

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Aprotinin is an enzyme which causes proteolysis of plasmin and kallikrein, so promoting haemostasis.

It is indicated for:

  • patients undergoing open heart surgery with circulatory bypass where control of haemorrhage is vital
  • hyperplasminaemia severe enough to promote massive haemorrhage e.g secondary to excessive thrombolytics

It is given by slow intravenous infusion or injection. Complications include hypersensitivity and local thrombophlebitis.

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