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In this form of haemolytic anaemia antibodies are formed against red cell antigens resulting in premature destruction of cells.
Cold haemagglutin disease is a reactive autoimmune haemolytic associated with IgM antibodies to red blood cells. These antibodies react best at low temperature.
Warm reactive autoimmune haemolytic anaemias are associated with IgG antibodies to red blood cells
Evidence suggests the combination of rituximab plus glucocorticoid (GC) may increase the rate of complete haematological response over GC monotherapy in newly diagnosed warm autoimmune haemolytic anaemia (1)