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Differential diagnosis

Authoring team

The differential diagnosis of CLL includes:

  • benign causes
    • B cell
      • postsplenectomy
    • T cell
      • bacterial (TB, syphilis) and viral (infectious mononucleosis, CMV) infections
      • serum sickness
      • thyrotoxicosis
      • postsplenectomy
  • malignant causes
    • B cell
      • prolymphocytic leukaemia
      • leukaemic phase of non-Hodgkin lymphoma
        • mantle cell lymphoma
        • marginal zone lymphoma
      • hairy cell leukaemia
      • Waldenstrom's macroglobulinaemia
    • T cell
      • T cell prolymphocytic leukaemia
      • prolymphocytic leukaemia
      • adult T cell leukaemia/lymphoma (1)

 

Reference:

  1. Eichhorst B, Robak T, Montserrat E, et al; ESMO Guidelines Committee. Chronic lymphocytic leukaemia: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021 Jan;32(1):23-33.

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