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World Health Organisation classification of acute myeloid leukaemia

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

WHO classification of AML includes:

  • Acute myeloid leukemia with recurrent genetic abnormalities which includes
    • AML with a translocation between chromosomes 8 and 21 [t(8;21)]*
    • AML with a translocation or inversion in chromosome 16 [inv(16) or t(16;16;)]*
    • acute promyelocytic leukemia (APL) which usually has translocation between chromosomes 15 and 17*
    • AML with a translocation between chromosomes 9 and 11 [t(9;11)]
    • AML with a translocation between chromosomes 6 and 9 [t(6;9)]
    • AML with a translocation or inversion in chromosome 3 [inv(3) or t(3;3;)]
    • AML(megakaryoblastic) with a translocation between chromosomes 1 and 22 [t(1;22)]
    • Provisional entity: AML with mutated NPM1
    • Provisional entity: AML with mutated CEBPA
  • Acute myeloid leukaemia with myelodysplasia-related changes
  • Therapy-related myeloid neoplasms
  • Acute myeloid leukaemia, not otherwise specified
    • AML with minimal differentiation
    • AML without maturation
    • AML with maturation
    • Acute myelomonocytic leukemia
    • Acute monoblastic/monocytic leukemia
    • Acute erythroid leukaemia
    • Pure erythroid leukaemia
    • Erythroleukemia, erythroid/myeloid
    • Acute megakaryoblastic leukemia
    • Acute basophilic leukemia
    • Acute panmyelosis with myelofibrosis

Reference:

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