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Aspirin at 75 mg/day reduces the risk of myocardial infarction in patients with unstable angina by about 50%.
A higher first dose of aspirin (e.g. aspirin 300mg) should give effective suppression of platelet activity from the start of therapy; thereafter, low-dose aspirin appears as effective as treatment in higher doses (1).
Ref: Drugs and Therapeutics Bulletin (1998), 36 (5), 36-9.