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Granulocytes (neutrophils) in blood transfusion

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

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Although clinical effectiveness of granulocytes (neutrophils) is debatable, it may be considered in patients with life-threatening soft tissue or organ infection with bacteria or fungi and low neutrophil counts, usually in the setting of severe, prolonged neutropenia after cytotoxic chemotherapy.

Two main granulocyte-rich components are used for transfusion:

  • buffy coats derived from whole blood donations
  • granulocytes collected by apheresis from individual donor

Granulocyte components must be ABO and RhD compatible and crossmatched with the recipient since it contains red cells (1)


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