GUSTO I investigated the role of thrombolysis and heparin in the treatment of myocardial infarction.
GUSTO II is investigated the role of hirudin, a specific inhibitor of thrombin, in the treatment of myocardial infarction.
GUSTO III compared tPA with a recombinant tPA-like molecule (reteplase). The two treatments were equally effective, however reteplase may be given as a bolus.
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