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Hereditary spherocytosis

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Hereditary spherocytosis is a disorder of the red blood cell membrane, leading to haemolytic anaemia. It is inherited as an autosomal dominant condition often linked to chromosome 8. It affects about 1 in every 5000 individuals in the United States.

The disorder is characterised by spherocytosis and increased numbers of reticulocytes on the peripheral blood smear. There is usually a positive family history.

Reference

  1. Zamora E. Hereditary Spherocytosis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan. 2023 Jul 4.

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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