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Low molecular weight heparin for acute ischaemic stroke

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Low molecular weight heparin has been trialled for the treatment of acute ischaemic stroke:

  • 312 patients within 48 hours of onset of ischaemic stroke
  • randomised to 4100 U of LMWH once or twice daily or placebo
  • treated for 10 days
  • followed for 6 months

The rates of mortality or dependency at 6 months were:

  • 45% for the twice daily LMWH group
  • 52% for the once daily LMWH group
  • 65% for the placebo group

The rates of haemorrhagic transformation were the same.


  • Kay, R. et al. (1995). Low-molecular-weight heparin for the treatment of acute ischemic stroke. NEJM, 333, 1588-93.

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