Laboratory events in monitoring sulphasalzine
Event: Value Action
Leucopaenia <3.5*10^9/l Stop & seek advice
Neutropaenia <2.5*10^9/l Stop & seek advice
Thrombocytopaenia <150*10^9/l Stop & seek advice
Macrocytosis >100 Check B12 and folate
Sequential falls >10% on Stop & seek advice in WCC or PMNs 3 occasions
Sequential falls >10% on Stop unless falls are from in platelets 3 occasions a high level, which is a response to treatment
Elevation of LFTs >3*normal Stop & repeat LFTs (AST, ALT, not ALP) Mild transaminitis is common
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