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PRoFESS trial

Authoring team

The PRoFESS trial (1) compared the efficacy of two treatments in secondary prevention of stroke:

  • 25 mg aspirin (ASA) and 200 mg extended-release dipyridamole twice a day, with
  • 75 mg clopidogrel once a day

Both regimens resulted in similar rates of recurrent stroke.

Reference:

1. Diener HC et al. Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurol. 2008 Oct;7(10):875-84.

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