Protein S deficiency results in a primary hypercoagulable state.
Both quantitative and qualitative abnormalities of protein S have been identified.
In the normal individual, 60% of protein S in the plasma is inactive, being bound to the C4b-binding protein. Excessive binding of protein S to C4b-binding protein may result in a deficiency of active protein S in the plasma.
Protein S deficiency is associated with (1):
Reference:
(1) British Heart Foundation (Factfile 2/2002). Thrombophilia.
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