This site is intended for healthcare professionals

Go to /sign-in page

You can view 5 more pages before signing in

Thalassaemia intermedia

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team

Thalassaemia intermedia refers to individuals who are either:

  • homozygous mild beta+ thalassaemia (1)
  • homozygous delta beta -thalassaemia - i.e. have combinations of beta+ and delta beta thalassaemic genes in which there is decreased delta and beta globin production but raised production of gamma chains
  • homozygous beta-thalassaemia but with hereditary persistence of foetal haemoglobin (1)- i.e. with high production of HbF
  • combination of beta thalassaemia with alpha thalassaemia (1)- clinically, resembles Hb H disease

These factors can reduce the affect and damage of free α chains within the developing erythroblast (1).

In this condition the production of β globins are reduced but are sufficiently available to allow growth and development without regular transfusions. Although transfusions maybe needed later to prevent later complication (1).

Symptoms may vary from none - thalassaemia minor - to anaemia, hepatosplenomegaly and bone deformities - thalassaemia major. There may also be recurrent leg ulceration, infections and gallstones.

Reference:


Create an account to add page annotations

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.