Treatment of the late stage
The 'burnt out' phase of primary erythrocytosis is indicated by:
- anaemia
- thrombocytopenia
- increasing hepatosplenomegaly
- fibrosis of the marrow
- leucoerythroblastic features in the blood
This heralds progression of the disease to acute leukaemia with increasing blast counts in the blood, often myeloid. Standard acute leukaemic therapy may be offered.
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