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Acyclovir is a deoxyguanosine analogue which is used to treat severe herpes virus infections.
A viral enzyme performs the first of three phosphorylations, the last two are by cellular enzymes with means that acyclovir is safe in non-infected cells.
73% is excreted in urine, and the CSF concentration reaches 50% plasma levels - thus it can be used in herpes encephalitis.
Routes of administration;
Resistance occurs in:
In the immune competent, resistant mutants are no problem. However in immune suppressed patients there is failure to heal, and chronic lesions form, especially in AIDS.