Flucytosine

Flucytosine has attained approval as an adjunct antifungal agent in treating systemic Candida spp. or Cryptococcus spp. infections.

Off-label, flucytosine is utilized in treating paediatric endocarditis caused by Aspergillus spp. (1)

Cautions: (2)

• blood disorders
• renal and hepatic impairment
• liver function tests and a full blood count are required
• pregnancy and breast feeding

Side-effects:

• rashes
• nausea and vomiting
• diarrhoea
• leucopenia
• thrombocytopenia
  
  

Routes of administration;

• Oral; Tablets
• IV infusion

References

1. McKeny T et al. Antifungal Antibiotics. Treasure Island (FL): StatPearls Publishing. 2025 Jan.
2. British National Formulary (BNF); NICE Evidence Services (UK access only)