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Cautions and contraindications

Last reviewed dd mmm yyyy. Last edited dd mmm yyyy

Authoring team


  • increase dose interval in renal impairment. In severe impairment the dose itself should also be reduced
  • check drug interactions - see current issue BNF


  • pregnancy - possible toxicity to eighth-nerve development of the fetus
  • myasthenia Gravis - aminoglycosides may impair neuromuscular transmission and indeed large doses given during surgery may be responsible for a transient myasthenic syndrome

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