Adverse reactions
Adverse Reactions to Polio-containing vaccine
Confirmed anaphylaxis occurs extremely rarely. Data from the UK, Canada and the US point to rates of 0.65 to 3 anaphylaxis events per million doses of vaccine given (1)
severe or mild systemic or local reaction within 72 hours of receiving a preceding vaccine. Immunisation with IPV-containing vaccine should continue following a history of (1):
- fever, irrespective of its severity
- hypotonic-hyporesponsive episodes (HHE)
- persistent crying or screaming for more than three hours
- severe local reaction, irrespective of extent
A previous version of the Green Book noted (2):
- pain, swelling or redness at the injection site are common and may occur more frequently following subsequent doses
- a small, painless nodule may form at the injection site; this usually disappears and is of no consequence
- incidence of local reactions is lower with tetanus vaccines combined with acellular pertussis vaccines, than with whole-cell pertussis vaccines and similar to that after DT vaccine
Reference:
- Immunisation Against Infectious Disease - "The Green Book".Chapter 26 Poliomyelitis (April 2019).
- Immunisation Against Infectious Disease - "The Green Book".Chapter 26 Poliomyelitis (August 2006).
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