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Differential diagnosis

Authoring team

  • the differential diagnosis includes:
    • acute human immunodeficiency virus infection (HIV) (1)
    • streptococcal tonsillitis
    • diphtheria
    • when lymphadenopathy is prominent:
      • leukaemia
      • toxoplasmosis
      • cytomegaloviral infection
    • when jaundice is the prominent feature:
      • infectious hepatitis
      • measles
      • rubella

Note:

  • acute cytomegalovirus (CMV) infection and toxoplasmosis may share many features with infectious mononucleosis (1)
    • these include:
      • splenomegaly
      • hepatomegaly
      • lymphocytosis
      • atypical lymphocytosis
      • false-positive results from a heterophile antibody test

Reference:

  1. Mark H. Ebell. Epstein-Barr Virus Infectious Mononucleosis. Am Fam Physician 2004;70:1279-87,1289-90.

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