a potent anthelmintic with a broad spectrum of activity against nematodes
well absorbed in the blood following oral administration
excreted almost entirely in the faeces
causes muscle paralysis in parasites via effects on ion-channels in cell membranes
his is the drug of choice for the treatment of onchocerciasis.
A single oral dose of 150 mcg/kg results in a prolonged reduction in filarial levels. Because the long-lived adults are not killed, retreatment at intervals of 6-12 months may be required for several years
adverse effects to treatment with invermectin are generally slight and usually take the form of temporary aggravation of itching and rash